We understand your work as a surgeon doesn’t end in the operating room- it ends when your patient heals and regains their quality of life.

In the US, roughly 500,000 surgical site complications occur each year, accounting for ~19.5% of all hospital readmissions and an estimated 8,000 patient deaths. Treating non-healing or infected surgical wounds costs the healthcare system over $13 billion annually^1-3. Despite modern advances, surgical teams are left asking: “Have we done everything possible to protect this wound?"

Driven by the belief that innovation can help make surgery safer and recovery faster, Gel4Med developed Suprello™: a next-generation, peptide-based surgical wound matrix to close that gap — advancing surgical wound protection for high-risk patients in high-stakes procedures.

Powered by Gel4Med’s Smart Materials Platform™, Suprello™ provides a resorbable scaffold that facilitates healing by supporting tissue regrowth, offers antibacterial protection to help manage wound bioburden, and integrates seamlessly into your existing workflow.

A close-up view of a syringe that contains Suprello wound matrix .

Suprello™ Surgical Wound Matrix

Suprello™ is a peptide-based surgical wound matrix specifically formulated for surgical wounds in high-risk cases. It is designed to support closure and help mitigate the risk of wound dehiscence and associated surgical wound complications.

By providing a scaffold for cellular infiltration and capillary growth while also protecting against multidrug-resistant organisms (MDROs)^4,5, Suprello™ helps create an optimal environment for wound healing in complex surgical scenarios. Its resorbable matrix conforms to the incision margins to support tissue apposition and wound closure over time⁶, working in harmony with the body’s natural healing process.

SKU #

G4M100M

GTIN

00850058790060

Brand Name

Suprello™ Surgical Wound Matrix, 2-mL pre-filled syringe with applicator tip

WOUND COVERAGE

20 cm²

Order Suprello^TM Wound Matrix

Leave nothing to chance in high-risk cases

A set of icons and description showing high risk criteria managed by Suprello.

Not every procedure will result in a surgical-site complication (SSC), but every SSC affects patients, outcomes, and resources. Evidence shows that patients with major comorbidities and complications, together with procedural risk factors, are at higher risk of developing SSC^8.

Suprello™ is intended for the local management of surgical wounds in high-risk cases and may help mitigate surgical wound complications⁶ by supporting healing and providing antibacterial protection^6,7.

Illustration of human body highlighting anatomic sites.

How Suprello™ Works

Illustration showing rapid tissue being absorbed.

Rapid tissue integration to support wound closure

Suprello™ surgical wound matrix is engineered to rapidly resorb and integrate into host tissue. As it integrates into the tissue, the matrix supports complete tissue apposition at the incision margins^6*, providing an environment conducive to wound healing.

Figure 1: In a swine full-thickness incisional wound model, Suprello™ achieved complete tissue apposition and full closure (100% re-epithelialization) of Methicillin-Resistant Staphylococcus aureus (MRSA)-infected wounds, with no signs of infection and complete material resorption by Day 7 post-op. Complete wound closure confirmed by 100% re-epithelialization was sustained at the end of the study (Day 21 post-op; data not shown).

*Preclinical data; clinical outcomes may differ.

Intimate contact and tissue compatibility

Suprello™ flowable formulation fully conforms to the surgical incision margins, creating an environment that supports wound closure. Its porous matrix structure⁷ allows for the diffusion of oxygen and nutrients, enabling cellular infiltration at the surgical site to facilitate wound healing.

Medical illustration of a porous wound matrix conforming to surgical incision margins.

Close-up of a surgical wound area protected by a glowing barrier or shield effect.

Strong antibacterial protection

Suprello™ provides broad-spectrum antibacterial protection against multidrug-resistant organisms (MDROs)^4,5, helping to mitigate the risk of infection in high-risk surgical cases. Its cationic peptides interact with and destabilize bacterial membranes⁹ through a physical mechanism of action, offering sustained antibacterial protection⁷ without tissue toxicity¹⁰ or risk of resistance development often associated with the use of antibiotics and antimicrobials.

Read the Suprello^TM White Paper for more information on antibacterial effectiveness.

Figure 2: In vitro, Suprello™ shows strong broad-spectrum antibacterial activity (10⁶ CFU reduction) against gram-positive and gram-negative antibiotic-resistant clinical isolates.

Explore the science behind Suprello^TM: View presentation

References

1. Najjar PA, et al. Surg Clin N Am 2015;95(2):269-283. 2. Merkow, R, et al. JAMA, February 3, 2015, Volume 313, Number 5.
3. Nussbaum SR, et al. An. Value Health. 2018 Jan;21(1):27-32. 4. Data on File. In vitro Antibacterial Studies. 5. Data on File. In Vitro and Ex-Vivo Antibiofilm Studies. 6. Data on File. In Vivo Incisional Wound Healing Study [Porcine Full-Thickness Incisional WoundHealing Model]. 7. FDA 510k submission package.
8. Hou Y, et al. Surg Open Sci. 2023 May 20;14:31-45. 9. Data on File. Investigating the Antibacterial Mechanism of Action of Self-Assembling Peptides.
10. Data on File. In vitro Cytocompatibility testing.

Medical product packaging with FDA 510(k) cleared label visible.

Designed for the operating room

Suprello™ features a sterile, ready-to-use system that includes a prefilled syringe and applicator tip, enabling precise contouring and delivery of the peptide matrix directly to the surgically created wound.

Suprello™ is FDA 510(k) cleared and available by prescription only under the supervision of a healthcare professional for the local management of partial and full-thickness surgical wounds:

• Room temperature-stable
• Three-year shelf life
• No reconstitution required
• Terminal steam sterilization
• Fully synthetic; no tissue tracking required

Suprello™ Surgical Wound Matrix

Suprello™ Surgical Wound Matrix

SKU #

GTIN

Brand Name

WOUND COVERAGE

Leave nothing to chance in high-risk cases

How Suprello™ Works

Rapid tissue integration to support wound closure

Intimate contact and tissue compatibility

Strong antibacterial protection

References

Designed for the operating room

Headquarters

R&D Laboratory

Suprello™ Surgical Wound Matrix

Suprello™ Surgical Wound Matrix

SKU #

GTIN

Brand Name

WOUND COVERAGE

Leave nothing to chance in high-risk cases

How Suprello™ Works

Rapid tissue integration to support wound closure

Intimate contact and tissue compatibility

Strong antibacterial protection

References

Designed for the operating room

Headquarters

R&D Laboratory

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